在SPRINT中的高灵敏度Troponin T,NT-proBNP和认知结果
Devin Haney1, Yuan Ma2, Djhenne Dalmacy1
1Department of Internal Medicine, University of Texas at Tyler Health Science Center (D.H., D.D., J.D.B.).
Hypertension (Dallas, Tex. : 1979)
|July 3, 2024
概括
高血压成年人的心脏生物标志物水平较低,可能会增强强度血压管理的认知益处. 强化治疗显示,在具有较低hs-cTnT和NT-proBNP水平的人群中,认知障碍的风险降低更大.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 高血压管理对于预防认知能力下降至关重要.
- 心脏生物标志物,包括高度敏感的心脏素T (hs-cTnT) 和N-终端亲B型尿素 (NT-proBNP),可能会对高血压患者的风险进行分层.
- 以前的研究表明,心脏生物标志物与认知功能之间存在联系.
研究的目的:
- 调查基线心脏生物标志物水平与高血压成年人轻度认知障碍 (MCI) 或可能痴呆症 (PD) 风险之间的关联.
- 根据SPRINT MIND研究中的hs-cTnT和NT-proBNP水平,确定强化降血压是否提供差异性认知益处.
主要方法:
- 利用了来自SPRINT MIND研究的数据,根据hs-cTnT和NT-proBNP三角形对8111名参与者进行了分类.
- 评估了MCI或PD的复合结果,平均随访时间为5.1年.
- 对比了强化与标准血压治疗对生物标志物类别的认知结果的影响.
主要成果:
- 心脏生物标志物类别最高的参与者患MCI或PD的风险更高 (HR,1.34).
- 强化血压治疗显示,在最低生物标志物三位数 (HR,0.64;P相互作用=0.02) 中,MCI或PD的风险降低显著更大.
- 强化治疗对MCI或PD的绝对风险降低在生物标志物类别中是可比的,尽管相对影响不同.
结论:
- 对认知功能的强度缩血压降低的相对益处似乎在高血压个体具有较低心脏生物标志物水平中更为明显.
- 虽然相对效应不同,但对认知障碍的绝对风险降低在生物标志物组中是相似的.
- Hs-cTnT和NT-proBNP可能有助于识别高血压患者,他们更有可能从积极的血压控制中从认知上受益.
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