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Updated: Jun 22, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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设计HVEM-LIGHT相互作用的抑制剂的多层计算框架.

Piotr Ciura1, Pamela Smardz2, Marta Spodzieja1

  • 1Faculty of Chemistry, Fahrenheit Union of Universities in Gdańsk, University of Gdańsk, Baż̇yńskiego 8, 80-309 Gdansḱ, Poland.

The journal of physical chemistry. B
|July 3, 2024
PubMed
概括

研究人员设计了针对疹病毒进入媒介 (HVEM) -LIGHT相互作用的受体抑制剂,以治疗自身免疫性疾病. 分子动力学模拟确定了一种强大的抑制剂,促进了免疫障碍的治疗策略.

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相关概念视频

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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