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Updated: Jun 22, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
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Published on: December 22, 2023

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一个镜像的脊椎决定的抗失律结构-活动关系,寡合性脱皮质天然产品

Madelaine P Thorpe1, Daniel J Blackwell2, Bjorn C Knollmann2

  • 1Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.

Journal of medicinal chemistry
|July 3, 2024
PubMed
概括

研究人员探索了循环寡合体脱类 (COD),并发现,ent-verticilide类似物通过抑制心脏通道 (RyR2) 显示出作为抗失常药物的潜力. 两种经过修改的化合物显示火花活性降低.

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