在妊娠年龄小于32周的早产婴儿的长期肺功能随访
Amaia Merino-Hernández1,2, Agustin Muñoz-Cutillas2,3, Cristina Ramos-Navarro1,2
1Neonatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Pediatric pulmonology
|July 3, 2024
概括
患有严重支气管肺功能障碍 (BPD) 的早产婴儿显示肺功能受损,即使经过肺保护策略. 严重的BPD和较轻的病例之间的肺功能差异仍然存在,这突显了严重的BPD对呼吸系统的长期影响.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 过早出生的婴儿,特别是那些患有支气管肺功能障碍 (BPD) 的婴儿,面临肺发育受损的风险.
- 几十年来,肺部保护策略已经减少了早产婴儿的慢性肺病.
研究的目的:
- 在实施肺部保护策略后,对早产婴儿进行肺功能测试 (PFT) 的评估.
- 在这个队列中确定与肺功能受损相关的围产期因素.
主要方法:
- 对新生儿<32周妊娠年龄 (2012-2014) 的前性,观察性,单中心研究.
- 随访到学龄,将BPD分类为没有BPD/第一年级和第二年级/3.3.
- 肺功能测试 (PFTs) 在平均年龄8.59岁时进行分析.
主要成果:
- 在116名婴儿中,49.1%患有BPD (1-3级).
- 患有BPD等级2/3的婴儿显示PFT参数 (FEV1,FVC,FEV1/FVC) 显著降低,而没有BPD/等级1的婴儿则显著降低.
- 在没有BPD的婴儿和1级BPD的婴儿之间没有发现PFT差异.
结论:
- 严重的BPD (2/3级) 与早产婴儿的肺功能下降有关,无论妊娠年龄如何.
- 阻塞性模式在患有BPD和异常PFT的早产婴儿中最常见,其次是限制性和混合模式.
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