在新生儿ICU中携带blaOXA-58的Acinetobacter junii的交叉传播
I Boudjella-Senhadji1, M Bour2, A Potron2
1Service d'Hygiène, Prévention et Contrôle des Infections, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
携带blaOXA-58碳烯耐药基因的Acinetobacter junii殖民了两个早产婴儿. 案例1是索引案例,SNP分析证实了对案例2的交叉传输.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 在新生儿重症监护室内,在两个早产婴儿身上发现了Acinetobacter junii携带blaOXA-58碳烯耐药基因的鼻子殖民.
- 这突显了医疗保健机构的潜在威胁,特别是对弱势群体的潜在威胁.
研究的目的:
- 为了确定两个早产婴儿分离的Acinetobacter junii是否在遗传上是相同的.
- 调查婴儿之间交叉传播的可能性.
主要方法:
- 抗生素敏感性测试和卡巴烯最小抑制度 (MIC) 的确定.
- 聚合酶链反应 (PCR) 检测 blaOXA-58 基因.
- 全基因组测序 (WGS) 随后进行单核酸多态性 (SNP) 分析以进行隔离物比较.
主要成果:
- 两个Acinetobacter junii分离物被证实是相同的菌株.
- 案例1被确定为索引案例,表明成功交叉传输到案例2.
结论:
- 在案例1中,这种耐卡巴胺菌株的获取可能与之前的卡巴胺治疗有关.
- 由于重症监护环境和婴儿的近距离,交叉传播是可能的.
- 这项研究代表了携带blaOXA-58基因的Acinetobacter junii交叉传播的第一个被记录的实例.
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