在儿童中非标签使用dalbavancin:一个案例系列
Anna Gamell1, Eneritz Velasco-Arnaiz1, Maria Goretti López-Ramos2
1Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain.
The Journal of antimicrobial chemotherapy
|July 3, 2024
概括
达尔巴万辛 (dalbavancin) 是一种治疗皮肤感染的抗生素,它在经批准的用途之外,对治疗复杂的儿科格拉姆阳性细菌感染有很大的希望. 这项研究发现,在儿童中,它对各种严重感染是安全有效的.
科学领域:
- 传染性疾病 传染性疾病
- 儿科药理学 儿科药理学
- 细菌学 细菌学是一门学科.
背景情况:
- 达尔巴万辛是一种抗生素,有效对抗格拉姆阳性细菌,主要用于急性细菌性皮肤和皮肤结构感染 (ABSSSI).
- 它的长半衰期促进了不太频繁的剂量使用,导致人们对其用于其他适应症的兴趣增加.
- 达尔巴万辛在非ABSSSI的儿科群体中的疗效和安全性尚未得到充分证实.
研究的目的:
- 为了评估达尔巴万辛在儿科患者的安全性和疗效,非ABSSSI由格拉姆阳性细菌引起.
- 评估dalbavancin在治疗复杂感染的有用性,如骨关节,导管相关的,以及儿童和青少年的其他严重感染.
- 确定使用达尔巴万辛的可行性,以提高儿科治疗方案的遵守性和方便性.
主要方法:
- 进行了一系列病例,涉及多种非ABSSSI的儿科患者接受达尔巴万辛治疗.
- 收集的数据包括患者人口统计,感染类型,致病原体,治疗持续时间,不良事件和治疗结果.
- 进行了后续评估,以监测复发和长期疗效.
主要成果:
- 15名儿科患者接受了dalbavancin,平均年龄为11.9岁;大多数患者有显著的并发症.
- 常见的感染包括深部手术部位感染,骨关节感染和与中心线相关的血液感染,主要是由金黄色葡萄球菌和 Staphylococcus epidermidis 引起的.
- 所有完成治疗的患者在中位数9.9个月的随访期间完全消除了感染,没有复发;由于可能发生不良事件,两人停止了治疗.
结论:
- 达尔巴万辛证明了安全性和有效性,作为选择的儿童患者的治疗选择,这些儿童患者患有复杂的格兰阳性细菌感染,超出了ABSSSI.
- 它的长半衰期提供了一个方便的替代方案,有可能改善儿科护理的遵守.
- 需要进一步的研究,以充分阐明达尔巴万辛在儿科传染病管理中的作用.
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