大脑结构,粉样蛋白和行为特征用于预测主观认知衰退的临床进展
Siwei Liu1,2, Xiao Luo3, Joanna Su Xian Chong1,2
1Centre for Sleep and Cognition, Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Human brain mapping
|July 3, 2024
概括
主观认知衰退 (SCD) 表明脑血管疾病 (CeVD) 负担增加,特别是在那些进展到轻度认知障碍的人群中. SCD状态预测未来的认知衰退,由白质超强度介导,而抑郁症直接影响结果.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年病的医生 老年病的医生
背景情况:
- 主观认知衰退 (SCD) 是阿尔茨海默氏症痴呆症的临床前阶段,与认知衰退和痴呆症的风险更高有关.
- 考虑到粉样蛋白沉积,脑血管疾病 (CeVD) 和精神病症状,SCD对临床进展的影响仍然不清楚.
研究的目的:
- 研究SCD对脑血管疾病 (CeVD) 和认知衰退的纵向影响.
- 为了确定SCD状态,年龄和抑郁症状是否预测老年人的临床结果.
主要方法:
- 利用了来自ADNI数据库的数据,比较正常对照组 (NC),进展SCD个体 (P-SCD) 和不进展SCD个体 (S-SCD).
- 评估的白质超强度 (WMH),包括深 (DWMH) 和周周 (PWMH) 区域,以及灰质体积.
- 采用结构方程建模来分析SCD,CeVD,抑郁症状和认知结果之间的纵向变化和关系.
主要成果:
- 与NC相比,SCD两组均表现出较高的基线和增加的纵向PWMH体积;P-SCD也显示出较高的基线和增加的DWMH体积.
- SCD状态与未来的WMH进展有关,基线SCD预测了PWMH介导的认知衰退.
- 抑郁症状直接导致临床结果,独立于CeVD.
结论:
- SCD与CeVD负担的增加有关,在那些进展到轻度认知障碍的人群中,这种增加更为明显.
- SCD状态主要通过CeVD病理,特别是白质超强度,影响未来的认知衰退.
- 多模态纵向研究对于理解SCD异质性和实现早期干预至关重要.
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