学术界中中枢神经系统药物发现:基础研究与创新相遇的地方
Jürg Gertsch1, Andrea Chicca1,2
1Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012, Bern, Switzerland.
Chembiochem : a European journal of chemical biology
|July 3, 2024
概括
在药物发现方面的学术研究面临着向临床试验过渡的挑战. 在 NCCR TransCure 中.
科学领域:
- 药物的发现和开发.
- 神经科学和药理学是神经科学和药理学.
- 生物技术和翻译医学
背景情况:
- 学术研究对药物发现的参与正在增加.
- 许多学术药物发现项目未能达到临床试验.
- 国家研究能力中心 (NCCR) 的TransCure专注于膜载体的早期药物发现,包括中枢神经系统 (CNS) 疾病中的疾病.
研究的目的:
- 评估NCCR TransCure内部的药物发现环境.
- 确定成功的学术药物发现和创新的关键要素.
- 对将早期研究转化为临床应用的挑战提供视角,特别是在中枢神经系统疾病中.
主要方法:
- 分析NCCR的TransCure倡议及其药物发现项目.
- 确定翻译研究的关键因素,如知识产权,资金和合作.
- 关于Synendos Therapeutics的案例研究,这是NCCR TransCure的一个分拆公司.
主要成果:
- 创新的关键要素包括波佩尔的伪造性,强大的知识产权和积极的创业团队.
- 学术界与工业界之间的合作,可持续的资金和思想冠军对翻译研究至关重要.
- 衍生公司Synendos Therapeutics正在开发用于神经精神疾病的选择性内分泌类固醇再吸收抑制剂 (SERIs).
结论:
- 弥合药物发现中的"死亡之谷"需要解决诸如动物模型不足和知识产权薄弱等挑战.
- 成功的学术药物发现需要专注于创新,强大的知识产权和有效的行业伙伴关系.
- NCCR TransCure的模型强调了学术研究有潜力为未满足医疗需求的新疗法做出贡献,以其分拆企业为例.
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