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不仅仅是肠道感觉――生理驱动溶解和药理动力学建模的结合,作为理解人类胃流动性的工具

Michał Romański¹, Marcela Staniszewska², Justyna Dobosz²

¹Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznań, Poland.

Molecular pharmaceutics

|July 3, 2024

概括

这项研究引入了一种新方法,将先进的溶解测试与药理动力学建模相结合,以了解胃机动性如何影响药物输送. 它揭示了五种不同的胃运动模式,影响健康成年人的药物吸收.

科学领域:

药理动力学和药物输送方法
胃肠道生理学胃肠道生理学
计算机建模计算建模

背景情况:

* 药物配方性能的体内研究面临挑战,因为对胃肠道相互作用的理解有限.
* 缩小体外/in silico模拟与体内结果之间的差距,需要先进的方法.
* 胃机动性对剂型性能的影响仍然是研究的关键领域.

研究的目的:

* 开发和验证一种新的方法来研究胃机动性对剂型性能的影响.
*将生物预测溶解测试与基于生理学的药理动力学建模相结合.
* 识别和描述影响药物吸收的胃运动模式.

主要方法:

*利用创新的PhysioCell装置进行生物预测溶解测试,使用生物相关介质,多种流体流和机械应力.
*采用了来自大量 (n=118) 禁食条件下的健康志愿者队列的药理动力学数据.
* 综合溶解数据作为机械,基于生理学的药理动力学 (PBPK) 建模的输入.

主要成果:

* 根据观察到的药理动力学概况,成功推断出五种不同的胃运动模式.
* 证明已确定的胃运动模式显著影响药物吸收和药物动力学结果.
* 量化了这些胃机动性模式在健康人群中的流行率.

结论:

* 拟议的方法提供了一个强大的工具,用于预测体外-体内生物药物性能.
*了解胃运动模式对于准确的药物配方开发和药理动力学预测至关重要.
*这种综合方法提高了立即释放口服剂型的生物预测能力.

关键词:

这就是PhysioCell.生物预测溶解测试生物预测溶解测试囊中的囊.胃肠道的胃肠道是什么样子的在体外体内生机建模.药物动力学药物动力学

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