线状真菌角膜炎的治疗策略 线状真菌角膜炎的治疗策略
Julia Storr1, Daniel Zapp2, Nathalie Bleidißel2
1Department of Ophthalmology, Klinikum Rechts der Isar, Technical University Munich (TUM), Ismaningerstr. 22, 81675, Munich, Germany. julia.storr@mri.tum.de.
Advances in therapy
|July 3, 2024
概括
丝状真菌角膜炎的诊断和治疗可能具有挑战性,由于抗真菌耐药性,往往导致不良结果. 纳塔米辛5%在治疗这种严重的眼部感染方面显示出有利结果的前景.
科学领域:
- 眼科医生 眼科 眼科
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
背景情况:
- 丝状真菌角膜炎是一种严重的眼睛感染.
- 准确的诊断和及时的治疗对于视觉结果至关重要.
- 了解流行病学和治疗疗效对于临床实践至关重要.
研究的目的:
- 描述线状真菌角膜炎的临床发现,流行病学和治疗结果.
- 为了比较不同抗真菌治疗的疗效.
- 评估添加剂局部类固醇在治疗真菌角膜炎中的作用.
主要方法:
- 在7年的时间里 (2013-2020年) 对25只患有丝状真菌角膜炎的眼睛进行了回顾性研究.
- 收集的数据包括最佳校正视敏度 (BCVA),临床症状,症状,风险因素和结果.
- 对抗真菌治疗方法的分析,包括局部纳塔米辛5%和沃里可纳2%,以及局部类固醇的使用.
主要成果:
- 68%的眼睛显示BCVA.BCVA的改善.
- 平均BCVA从0.75提高到了0.48 logMAR.
- 局部纳塔米辛5%和沃里可纳2%的组合是最常见的治疗方法 (44%).
- 在52%的病例中使用了局部类固醇,在16%的病例中使用了穿透式角质整形.
结论:
- 细丝真菌角膜炎的诊断往往会延迟,影响结果.
- 高抗真菌耐药性导致治疗结果差.
- 获得局部纳他素5%似乎与真菌角膜炎的良好结果有关.
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