遗传学和睡眠乱症:对双胞胎的研究进行了系统性审查和元分析
Laiane Fernandes Pereira1, Francisco Wilker Mustafa Gomes Muniz2, Marina de Deus Moura de Lima3
1Postgraduate Program in Dentistry, Federal University of Piaui, Teresina, Piaui, Brazil.
Sleep & breathing = Schlaf & Atmung
|July 3, 2024
概括
这项研究发现,单胞胎 (MZ) 双胞胎的睡眠布鲁克西斯 (SB) 协同性高于双胞胎 (DZ) 双胞胎. 这表明潜在的遗传影响睡眠布鲁克斯症的发生.
科学领域:
- 遗传学 是一个遗传学.
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 睡眠 (Sleep bruxism,SB) 是一种在睡眠期间发生的耳鼻面部运动障碍.
- 了解SB的病因,包括遗传和环境因素,对于开发有效的干预措施至关重要.
- 双胞胎研究对于解开遗传和环境对复杂疾病的贡献是有价值的.
研究的目的:
- 系统地审查和综合现有关于单胞胎 (MZ) 和双胞胎 (DZ) 双胞胎之间睡眠 (SB) 的一致性文献.
- 通过双胞胎一致率来评估睡眠布鲁克斯症的潜在遗传性.
- 提供不同类型的双胞胎SB一致性的定量估计.
主要方法:
- 在四个主要数据库 (PubMed,Scopus,Embase,Web of Science) 和灰色文献来源中进行了系统的文献搜索.
- 报告MZ和DZ双胞胎SB的观察性研究被纳入了定性和定量 (元分析) 评估.
- 使用Joanna Briggs检查清单评估偏见风险,使用GRADE系统评估证据的确定性.
主要成果:
- 在11项纳入的研究中,有7项为分析做出了贡献,其中大多数具有低偏差风险.
- 与DZ双胞胎相比,MZ双胞胎之间观察到SB的一致性明显更大 (一般一致性OR=1.47;积极一致性OR=1.53).
- 亚组分析证实了报告/自我报告的SB的这些发现,证据的确定性低至中等.
结论:
- 这些发现表明,与双胞胎双胞胎相比,单胞胎双胞胎的睡眠布鲁克斯症的一致率更高.
- 这表明,一个显著的遗传成分,有助于睡眠 Bruxism 的易感性和发生.
- 需要使用强大的方法进一步研究,以阐明SB的精确遗传基础.
相关概念视频
Behavioral Genetics and Its Designs
352
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
352
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Human Genetics
556
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
556
Case Studies
11.6K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
11.6K
Blind Procedures
10.6K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.6K
Teeth
373
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
373


