发现胰岛素受体基质在白免疫中的功能,通过活性免疫
Wei Zhou1, Xingying Zhao1, Ali Hassan1
1Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, Huazhong Agricultural University, Wuhan 430070, China.
Journal of insect science (Online)
|July 3, 2024
概括
在白中抑制胰岛素受体基质 (IRS) 基因破坏了葡萄糖和脂质代谢,损害了社会免疫和抗真菌防御. 这突出了国税局的重点.
科学领域:
- 昆虫生理学 昆虫生理学
- 社会豁免权社会豁免权
- 代谢调节 代谢调节 代谢调节
背景情况:
- 胰岛素受体基质 (IRS) 蛋白质对于胰岛素信号通路至关重要.
- 虽然IRS在社会昆虫种群和食中的作用是已知的,但它们在疾病防御中的功能仍然未被探索.
研究的目的:
- 调查IRS在白活跃免疫和疾病防御中的作用.
- 了解白胰岛素信号传递和社会免疫之间的联系.
主要方法:
- 用RNA干扰 (RNAi) 来抑制白中的IRS基因.
- 分析了新陈代谢特征 (葡萄糖,三糖,糖原,甘油三,酸盐).
- 评估了行为测试 (修饰) 和免疫基因表达 (GNBP2,termicin,caspase8).
- 评估了抗真菌活性和生存率.
主要成果:
- IRS基因抑制导致代谢障碍,包括改变的葡萄糖和脂质水平.
- 抑制的IRS增强了暴露于真菌的巢友的理行为,增加了真菌负荷.
- 观察到免疫基因 (GNBP2,termicin) 的降低调节和亡基因 (caspase8) 的上调调节.
- 抗真菌活性下降,IRS抑制的白的生存率下降.
结论:
- IRS在调节白的活性免疫和社会免疫方面发挥着重要作用.
- 胰岛素信号与社会昆虫的代谢平衡和疾病防御机制有关.
- 了解IRS的功能,可以了解社会昆虫免疫力的演变.
相关概念视频
Insulin: The Receptor and Signaling Pathways
1.2K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.2K
Insulin Secretory Vesicles
4.9K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
4.9K
Insulin: Biosynthesis, Chemistry, and Preparation
370
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
370
Active versus Passive Immunity
617
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
617


