早期前列腺癌死亡率在具有更高或更低遗传风险的男性中
Anna Plym1,2,3, Yiwen Zhang2, Konrad H Stopsack2,4
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
JAMA network open
|July 3, 2024
概括
患前列腺癌的遗传风险较高的男性显著增加了早期死亡率. 这些死亡中有很大一部分可以通过健康的生活方式选择来预防,强调有针对性的预防策略.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学是一种遗传学.
- 预防医学 预防医学
背景情况:
- 前列腺癌是男性癌症死亡的主要原因,需要新的预防策略.
- 针对具有遗传易感性的个体可能为预防提供了一个有希望的途径.
研究的目的:
- 研究遗传风险与前列腺癌早期死亡率之间的关联.
- 通过分析风险差异,为前列腺癌预防工作提供信息.
主要方法:
- 一项队列研究结合了马尔默饮食和癌症研究 (MDCS) 和卫生专业人员随访研究 (HPFS) 的数据.
- 男人根据遗传风险 (多基因风险评分或家族病史) 和生活方式行为进行分类.
- 时间到事件分析被用来评估前列腺癌死亡率.
主要成果:
- 与基因风险较低的男性相比,具有较高遗传风险的男性在前列腺癌早期和晚期死亡率显著增加.
- 更高的遗传风险与更高的前列腺癌终身死亡风险有关.
- 在具有较高遗传风险的男性中,很大一部分 (36%) 的早期前列腺癌死亡是可以通过坚持健康的生活方式来预防的.
结论:
- 患有前列腺癌的遗传倾向的男性占前列腺癌早期死亡的大多数.
- 这些早期死亡的很大一部分是可以预防的,这强调了改变生活方式的重要性.
- 针对性前列腺癌预防策略应专注于基因风险增加的男性.
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