农作物中的制药残留物是否对人类健康构成威胁?
Kirsten Earl1, Harriet Sleight1, Nahum Ashfield1
1Department of Environment and Geography, University of York, York, Heslington, UK.
概括
土壤中的人类和兽医药品可能会转移到作物中,导致食用暴露. 虽然通常是安全的,但一些药物,如卡巴马泽平和trimethoprim/sulfamethoxazole,通过受污染的作物构成潜在的健康风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 来自生物固体,肥料和废水的药物进入农业土壤.
- 农作物吸收与土壤结合的药品可能会导致人类通过饮食暴露.
- 通过饮食偶尔接触药物的风险尚不清楚.
研究的目的:
- 评估人类对农作物中药物残留物的暴露.
- 评估与食用含有药品的作物相关的健康风险.
- 分析农业土壤中经常检测到的药品.
主要方法:
- 估计的土壤度的卡巴马泽,牛氧三环素,硫甲醇,trimethoprim,和四环素.
- 利用植物吸收和作物消费数据来估计人类每日暴露.
- 对风险评估的可接受每日摄入量 (ADI) 的估计暴露水平进行比较.
主要成果:
- 大多数估计的药物暴露低于ADI.
- 在最坏的情况下,卡巴马西平的暴露超过了ADI.
- 在保守的假设下,甲和硫甲醇的暴露超过了ADI.
结论:
- 通过农作物通过饮食接触某些药品可能会对健康构成风险.
- 卡巴马泽平,三甲和硫甲醇需要进一步调查.
- 优先研究食用污染作物的健康影响.
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