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Updated: Jun 22, 2025

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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非病毒CRISPR/Cas9突变发生为简化生成小鼠肺癌模型

Irene Lara-Sáez1, Ángeles Mencía2,3,4, Enrique Recuero2,5

  • 1Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin D04 V1W8, Ireland.

Proceedings of the National Academy of Sciences of the United States of America
|July 3, 2024
PubMed
概括

研究人员开发了一种新的CRISPR/Cas9方法,用于创建肺癌小鼠模型. 这种具有成本效益的方法可以使基因同时不活化,促进在瘤发育中的多个基因的研究,并帮助癌症相关基因的功能测试.

关键词:
这是一种CRISPR/Cas9核糖蛋白.在SCLC中,SCLC是最重要的.在体内进行基因编辑.肺癌模型 肺癌模型

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