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与DC队列中初始抗逆转录病毒疗法停止的时间相关的因素
Morgan E Byrne1, Jenna B Resnik1, Michael A Horberg2
1Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia, USA.
AIDS research and human retroviruses
|July 3, 2024
概括
女性,社区诊所的参与者,以及那些使用蛋白酶抑制剂治疗方案的人更有可能停止初始抗逆转录病毒疗法 (ART). 这凸显了对艾滋病毒感染者的更好的患者支持和灵活的治疗选择的需要.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 抗逆转录病毒疗法 (ART) 对于治疗艾滋病毒至关重要,如果初始治疗方案有效且能耐受,通常可以长期维持.
- 之前的研究表明,治疗方案类型,性别,艾滋病毒传播途径和CD4计数等因素影响了ART的持续时间.
- 了解最初的ART停止是改善治疗坚持和患者结果的关键.
研究的目的:
- 在新诊断的,病毒未抑制的艾滋病毒感染者 (PWH) 中,确定与停止初始抗逆转录病毒疗法 (ART) 相关的因素.
- 分析DC队列的人口统计和临床数据,以确定较短的初始ART持续时间的预测因素.
主要方法:
- 从前性DC队列研究中分析了479名新诊断的,病毒未被抑制的PWH的子集.
- 排除在注册时不到6个月的随访或病毒抑制的参与者.
- 利用电子健康记录数据来评估最初停止ART治疗的时间和相关因素.
主要成果:
- 最初停止ART治疗的中位数时间为2.7年.
- 女性 (aHR 1.55),基于蛋白酶抑制剂的治疗方案的个人 (aHR 1.87) 和社区诊所 (aHR 1.46) 的患者的停药时间显著缩短.
- 研究样本主要是男性 (79.1%) 和黑人 (70.8%),平均年龄为33.9岁.
结论:
- 最初的ART中止在女性,服用蛋白酶抑制剂的患者和那些参加社区诊所的患者中更为常见.
- 这些发现表明需要加强患者咨询和可能更具适应性的ART策略.
- 针对特定的患者群体和护理环境可以改善长期的ART坚持和艾滋病毒管理.
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