门德尔随机化分析澄清了身高对心血管疾病的影响
Daniel Hui1, Eric Sanford2, Kimberly Lorenz3,4,5,6
1Graduate Program in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, United States of America.
PloS one
|July 3, 2024
概括
更短的身高与冠状动脉疾病 (CAD) 风险增加有关,但当考虑到已确定的心血管风险因素时,这种关联显著减少. 肺功能并不能解释残留的身高与CAD的联系.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 心血管疾病 心血管疾病
背景情况:
- 观察性研究和门德尔随机化 (MR) 表明人体身高与冠状动脉疾病 (CAD) 风险之间存在逆相关性.
- 心血管,人体测量,肺功能和生活方式因素在多大程度上调解了这种高度-CAD关联,目前尚不清楚.
研究的目的:
- 调查身高与CAD风险之间的因果关系,并确定已确定的风险因素在多大程度上解释了这种关联.
- 为了澄清肺功能特征在身高-CAD关系中的作用.
主要方法:
- 利用了一个大规模的遗传数据集,包含1800多种高度和CAD的遗传变异.
- 采用单变量和多变量门德尔随机化分析.
- 占据了多达12个已确定的心血管,人体,肺功能和生活方式风险因素.
主要成果:
- 证实了反向关联:身高下降1个标准偏差 (~6.5厘米) 增加了12.0%的CAD风险.
- 多变量分析显示,经过调整风险因素后,身高对CAD风险的因果作用减弱了超过3倍 (3.7%,p = 0.02).
- 在此分析中,肺功能特征对CAD风险的影响很小,无法解释剩余关联.
结论:
- 身高对冠状动脉疾病风险的独立影响,超出已确定的心血管风险因素,是最小的.
- 肺功能测量似乎无法解释身高与CAD风险之间的残留关联.
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