在一个被囚禁的殖民地的全球和本地祖先估计
Christopher Kendall1, Jacqueline Robinson2, Guilherme Debortoli3
1Department of Anthropology, University of Toronto, Toronto, Ontario, Canada.
PloS one
|July 3, 2024
概括
对的遗传祖先分析揭示了历史上的混合和血统错误. 这项研究为灵长类研究提供了最新的遗传资源和祖先信息标记.
科学领域:
- 灵长类动物遗传学
- 进化生物学是进化的生物学.
- 人口遗传学 人口遗传学
背景情况:
- 杂交研究对于理解灵长类动物进化至关重要.
- 巴 (Papio) 遗传研究从详细的祖先信息中受益.
研究的目的:
- 通过使用密集的基因组数据来估计被囚禁的的遗传祖先.
- 为了识别历史混合和血统不准确.
- 为了改善未来研究的遗传资源.
主要方法:
- 使用了881只 (Papio anubus,Papio cynocephalus和杂交物) 的密集,完整基因组数据.
- 对低覆盖率样本进行了基因组归算 (n=830).
- 比较分相/归算管道和全球祖先估计软件.
主要成果:
- 在所谓的纯种身上检测到历史上的混合物.
- 在西南国家灵长类动物研究中心的血统中发现了错误.
- 在全球祖先软件 (R2 > 0.88) 之间发现了良好的协议,但管道依赖的相切换错误.
结论:
- 遗传祖先估计可以揭示隐藏的混合物和血统问题.
- 更新的遗传地图和祖先信息标记 (n=1,747) 现已提供.
- 这项工作增强了研究和进化研究的遗传资源.
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