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Updated: Jun 22, 2025

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瘤抑制剂FRMD3通过隙信号通路控制乳腺上皮细胞命运的决定

Ji Ma1, Yuqing Gong1, Xiaoran Sun1,2

  • 1Program for Cancer and Cell Biology, Department of Human Anatomy, Histology, and Embryology, School of Basic Medical Sciences, and Peking University International Cancer Institute, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing 100191, China.

Science advances
|July 3, 2024
PubMed
概括

丢失含有FERM域的蛋白3 (FRMD3) 会损害乳腺发育,促进干性,导致三阴性乳腺癌. FRMD3通过激活Notch信号来作为瘤抑制剂,这对乳腺上皮细胞可塑性至关重要.

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