细胞外膀ASC:在早产大脑损伤中,肺脑轴的新型调解器
Natalie Starke1, Naga Venkata Divya Challa1, Huijun Yuan1
1Division of Neonatology, Department of Pediatrics, Batchelor Children's Research Institute, Holtz Children's Hospital.
概括
携带ASC的细胞外囊泡从高氧的早产婴儿身上产生,有助于肺和大脑损伤,模仿支气管肺功能障碍 (BPD) 和神经发育障碍.
科学领域:
- 新生儿医学 新生儿医学
- 肺部病理学 肺部病理学
- 神经科学是一个神经科学.
背景情况:
- 支气管肺功能障碍 (BPD) 和神经发育障碍在早产婴儿中很常见.
- 将BPD与脑损伤联系在一起的机制尚不清楚.
- 细胞外囊泡 (EVs) 在疾病中调解器官间的通信.
研究的目的:
- 调查膜巨 (AM) 衍生的EVs在BPD病原和相关脑损伤中的作用.
- 评估高氧暴露对早产婴儿EV-ASC含量的影响.
- 为了确定从高氧暴露的婴儿转移EV的功能后果.
主要方法:
- 在早产婴儿的血EV中评估了AM标志物 (CD11b,CD11c,CD206) 和ASC.
- 在高 (HO2) 与低 (LO2) 分数的吸入氧的婴儿中,量化AM衍生的EV-ASC.
- 对新生小鼠进行了EVs的收养转移,以评估肺部和大脑的影响.
主要成果:
- 接受HO2的婴儿表现出AM衍生的EV-ASC度增加.
- 采用HO2-EVs转移到小鼠中诱导了肺炎,损害了膜化和BPD特征的血管缺陷.
- HO2-EVs 穿越了血脑屏障,导致海马体炎症,细胞存活率降低,细胞死亡 (pyroptosis,necroptosis).
结论:
- 在BPD病变发生过程中,AM衍生的EV-ASC介导肺与大脑交叉交谈.
- 这一途径有助于早产婴儿的肺损伤 (BPD) 和脑损伤.
- 来自AM的EV-ASC代表了BPD和相关的大脑损伤的潜在治疗点.
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