针对抑郁症的免疫向疗法:目前关于单克隆抗体抗抑郁作用的证据
Mina M Rizk1,2,3, Lindsay Bolton2, Flurin Cathomas4,5
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
The Journal of clinical psychiatry
|July 3, 2024
概括
单克隆抗体 (mAbs) 在治疗耐药性抑郁症方面表现有前途. 虽然一些mAbs在炎症条件下改善了伴随性抑郁症,但需要进一步的研究来确认它们在原发性抑郁症中有效性和安全性.
科学领域:
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 耐治疗抑郁症 (TRD) 仍然是一个重大的临床挑战.
- 免疫调节药物,包括单克隆抗体 (mAbs),正在成为潜在的治疗选择.
- 与传统抗抑郁药相比,mAbs提供了一种新的作用机制.
研究的目的:
- 对单克隆抗体 (mAbs) 抗抑郁作用的新兴证据进行范围审查.
- 探索mAbs在治疗抑郁症,特别是耐治疗形式中的潜力.
- 确定当前关于mAb在初级抑郁症中使用的研究中的差距.
主要方法:
- 在PubMed进行了全面的文献搜索,截至2023年11月.
- 包括的研究包括元分析,随机对照试验,开放标签研究,单臂研究和病例系列.
- 分析了专注于mAbs抗抑郁作用的英语出版物.
主要成果:
- 几种mAbs表现出潜在的抗抑郁作用,主要观察到患有轻度抑郁症并发性炎症疾病的患者.
- 在患有初级抑郁症的人群中,infliximab和sirukumab是唯一直接研究的mAbs.
- 像ixekizumab和dupilumab这样的mAbs,不需要实验室监测,在等待对自杀风险的安全评估时显示出有希望.
结论:
- 用于炎症状况的mAbs已经显示出对伴随性抑郁症状的好处.
- mAbs代表了潜在的新疗法途径,用于抑郁症患者不响应现有治疗.
- 进一步的研究至关重要,重点是重症抑郁症和初级抑郁症中mAbs的直接评估.
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