葡萄糖的流失模式识别了先前没有服用过抗精神病药物的患者,患有第一发精神病症
Helle G Andersen1, Brian DellaValle2, Hjalte Bøgehave2
1Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Centre Glostrup, Copenhagen University Hospital, Glostrup, Denmark; Copenhagen Research Centre for Mental Health and VIRTU Research Group, Mental Health Centre Copenhagen, Denmark.
Psychiatry research
|July 3, 2024
概括
血液中的生物标志物
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 精神疾病与免疫功能障碍和神经炎症有关.
- 受损的血脑屏障 (BBB) 与精神病有关.
- 内皮葡萄糖 (GLX) 对于BBB完整性至关重要;其脱落表明功能障碍.
研究的目的:
- 为了确定外围GLX分子是否可以区分早期精神病患者与健康对照.
- 为了研究GLX流失和精神病症状严重程度之间的相关性.
主要方法:
- 分析了一组11个GLX分子的小组,来自之前未服用过抗精神病药物的第一发精神病患者 (n=47) 和健康对照组 (n=49) 的血清.
- 利用机器学习模型根据GLX标记模式对患者群体进行分类.
- 探索GLX标志物与临床症状严重程度之间的关联.
主要成果:
- 与对照组相比,精神病患者的三个GLX标志物显著升高.
- 机器学习模型在根据11个GLX标志物对患者进行分类时,达到81%的准确率.
- 增加的GLX标志物与患者的症状严重程度更大相关.
结论:
- 外围GLX分子显示出作为早期精神病检测的免疫神经精神病学生物标志物的潜力.
- 在早期精神病中,GLX流失表明血脑屏障受损.
- 需要进一步的研究来验证GLX在早期精神病诊断中的作用.
相关概念视频
Glycocalyx and its Functions
3.9K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
3.9K
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
73
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
73
Psychosis and Antipsychotic Drugs: Overview
229
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
229
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
564
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
564
Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48


