在患有的儿童中治疗状态的肠道胺
Laura DiDomenico1, Lisa C Garrity2, Kelsey E Poisson3
1Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
肠内胺有效治疗儿童的状态 (SE),减少发作的频率,并可能防止输管. 这项研究强调了它在儿科病例中的安全性和有效性.
科学领域:
- 儿科神经学 儿科神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 状态 (SE) 影响10-20%的儿童.
- 患有集群的儿童面临着更高的SE风险.
- 对于SE的胺使用在儿科患者中正在增加.
研究的目的:
- 为了评估肠内胺的疗效和安全性.
- 评估对抗性发作集群的性状态 (CSE) 的治疗方法.
- 在患有的儿童中检查非状态 (NCSE) 的治疗方法.
主要方法:
- 儿科患者 (1-21岁) 与SE治疗肠内胺的回顾性图表审查.
- 在2021年9月至2022年9月期间在儿科三级护理中心收集的数据.
- 评估了发作的解决/减少,输管,住院时间,副作用和再接收.
主要成果:
- 确定了9名患有和SE的患者 (2-21岁).
- 七名患者在服用胺后48小时内出现了发作解脱或减少.
- 两名患者需要输管治疗;住院时间各不相同,一些重新入院患者的住院时间较短.
结论:
- 肠道胺似乎对儿科SE (CSE和NCSE) 有效且耐受良好.
- 它可能有助于预防输管治疗,并减少患有的儿童住院时间.
- 这种治疗方法看起来很有前途,特别是在遗传性方面.
更多相关视频
08:43Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
Published on: July 21, 2015
09:57Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
相关概念视频
Parenteral Anesthetics: Overview
Drug Delivery: Enteral Route
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Antiepileptic Drugs: Calcium Channel Blockers
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Arteries of the Lower Limbs
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
