在非小细胞肺癌中调节肠道微生物群:挑战和机遇
Jii Bum Lee1, Yiqing Huang2, Yuko Oya3
1Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Lung cancer (Amsterdam, Netherlands)
|July 3, 2024
概括
肠道微生物群影响非小细胞肺癌 (NSCLC) 免疫治疗的有效性. 通过便微生物种移植 (FMT) 或活生物治疗产品 (LBPs) 利用微生物组,可以改善NSCLC患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫疗法对非小细胞肺癌 (NSCLC) 有效,但许多患者在很少的选择下复发.
- 新兴研究表明,肠道微生物组可以增强在上皮瘤中的免疫治疗反应.
- 了解肺和肠道微生物组在NSCLC中的作用对于改善患者的治疗结果至关重要.
研究的目的:
- 审查肺和肠道微生物组在NSCLC中的作用.
- 总结微生物组影响化疗和免疫疗法的疗效和毒性的机制.
- 讨论正在进行的临床试验,研究基于微生物组的疗法,如便微生物群移植 (FMT) 和活生物治疗产品 (LBPs) 对NSCLC.
主要方法:
- 关于NSCLC微生物组的临床前和临床研究的文献综述.
- 对将微生物组组成与治疗反应和毒性联系起来的拟议机制的分析.
- 目前临床试验的概述,涉及NSCLC微生物组调制.
主要成果:
- 临床前数据表明,微生物组调制可以提高免疫疗法的疗效.
- 微生物组影响癌症治疗的有效性和副作用.
- 临床试验正在积极探索FMT和LBP作为新的NSCLC治疗策略.
结论:
- 微生物组是增强NSCLC免疫疗法的有希望的目标.
- 需要对微生物组-肠-肺轴相互作用进行进一步的研究.
- 便微生物群移植 (FMT) 和活生物治疗产品 (LBPs) 显示出改善NSCLC治疗的潜力.
相关概念视频
What is Monogastric Digestion?
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


