特性,体外老年人消化,和器官细胞吸收的黄素装载的纳米粒子
Leiyu Deng1, Ruijie Wang1, Xiankang Xu1
1Food Nutrition Science Center, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.
Food chemistry
|July 3, 2024
概括
使用OSA粉和 kazeinate的库尔库明纳米颗粒增强了老年人的消化和吸收. 这些配方改善了黄素的运输和生物可用性,为营养策略提供了洞察力.
科学领域:
- 食品科学 食品科学 食品科学
- 营养科学 营养科学
- 生物技术是生物技术.
背景情况:
- 黄素表现出抗炎和抗癌的特性.
- 老年人库尔库的生物命运和吸收在很大程度上仍然没有特征.
- 需要有效的输送系统来提高黄素的生物可用性.
研究的目的:
- 开发和描述使用酸酸酸 (OSA) 粉和酸的素载纳米颗粒.
- 在老年模型中研究这些纳米颗粒的体外消化和吸收.
- 评估纳米颗粒封装对黄素运输和与脂质代谢相关的基因表达的影响.
主要方法:
- 使用OSA粉 (HI), kazeinate (SC) 和一种组合 (HS) 制备含有黄素的纳米颗粒.
- 使用老年人模拟消化模型进行体外消化和吸收试验.
- 对黄素释放动力学,运输效率和透性的分析.
- 评估肠道有机体中的基因表达变化 (TNF-α,SREBP2,NPC1L1).
主要成果:
- 在所有纳米粒子配方中,黄素的负载能力超过了15%.
- 在体外消化过程中,黄素的释放跟随了第一阶动力学.
- 纳米颗粒配方显著提高了黄素的运输效率 (约. 1倍) 和透性 (1.9-2.0倍) 与自由黄相比.
- 在有机体中观察到TNF-α,SREBP2和NPC1L1基因表达的升级.
结论:
- OSA粉和甲酸盐是封装黄素的有效矩阵.
- 含有黄素的纳米颗粒显示出改善的体外消化和吸收特性,这与老年人有关.
- 这些发现为利用黄素纳米颗粒在老年人营养和健康干预中提供了科学基础.
更多相关视频
相关概念视频
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
813
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
813
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
333
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
333