面部热图像分析揭示了衰老和代谢疾病的定量标志
Zhengqing Yu1, Yong Zhou2, Kehang Mao1
1Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, China.
Cell metabolism
|July 3, 2024
概括
面部温度随着年龄的变化而变化,一种新的深度学习方法,ThermoFace,可以预测热年龄. 这种预测与健康标志物相关,并受运动等生活方式因素的影响.
科学领域:
- 老年学是指老年学的学科.
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 人的核心体温随着年龄的增长而下降.
- 面部温度与衰老速度或与年龄相关的疾病之间的关系尚未得到充分理解.
研究的目的:
- 为了研究面部温度的年龄依赖性.
- 开发一种自动化面部热分析方法.
- 创建热年龄和疾病风险的预测模型.
主要方法:
- 收集了2811名汉族中国人 (年龄在20-90岁) 的热面部图像.
- 开发了ThermoFace深度学习方法用于图像处理和分析.
- 生成的热年龄和疾病预测模型.
主要成果:
- 该ThermoFace模型准确地预测了面部热年龄,平均绝对偏差约为5年.
- 预测年龄和时间年龄之间的差异与代谢参数,睡眠和基因表达 (DNA修复,脂解,ATPase) 有关.
- 运动可以改变这种年龄差异.
- ThermoFace的疾病预测器准确地预测了诸如脂肪肝 (AUC > 0.80) 等代谢疾病.
结论:
- 面部热成像为老化过程提供了洞察力.
- ThermoFace为评估生物年龄和代谢健康提供了一个非侵入性的工具.
- 生活方式干预,如运动,可能会影响面部温度所显示的衰老轨迹.
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