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暂时受体潜能通道5的丧失导致肥胖和产后抑郁症

Yongxiang Li¹, Tessa M Cacciottolo², Na Yin¹

¹USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

|July 3, 2024

概括

暂时受体潜能 (TRP) 通道5 (TRPC5) 删除会影响本能行为. TRPC5 损失与寻找食物,肥胖,焦虑,男性自闭症和女性产后抑郁症有关.

科学领域:

神经科学
遗传学
行为科学

背景情况:

脑下神经回路控制着基本的本能行为, 如食,应激反应,社会互动和母亲的照顾.
暂时受体潜力 (TRP) 道对于大脑的感官信号传输至关重要.

研究的目的:

调查瞬态受体潜能 (TRP) 频道5 (TRPC5) 在调节本能的行为中的作用.
在人类和动物模型中确定TRPC5基因变异的后果.

主要方法:

对影响TRPC5表达的Xq23染色体微切除的鉴定.
产生具有人类功能丧失TRPC5突变的克诺基因小鼠.
在雄性和雌性TRPC5删除载体和克洛因小鼠的行为表型分析.
在下丘脑侧腔核的催产素神经元中研究TRPC5功能.

主要成果:

雄性TRPC5删除载体和敲击小鼠表现出增加的食物寻找,肥胖,焦虑和类似自闭症的行为.
携带TRPC5缺失的女性患有严重的产后抑郁症.
雌性鼠表现出无情感,类似抑郁症的行为,以及受损的母性护理.
催产素神经元中的Trpc5缺失导致肥胖和女性产后抑郁行为;Trpc5过度表达逆转了这些表型.

结论:

TRPC5 在调解生存必不可少的先天性行为方面至关重要,包括寻找食物和照顾母亲.
TRPC5 功能障碍导致人类和小鼠的一系列行为障碍.
催产素神经元和TRPC5信号对调节食欲和母亲行为至关重要.

关键词:

TRP 道焦虑自闭症大脑下垂体具有天生的行为肥胖问题产后抑郁症传感信号

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