相关实验视频
Updated: Jun 22, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
维生素D3通过通过YAP/JAK1/STAT1轴调节Th17/Treg细胞分化来减轻自身免疫性甲状腺炎
Qiang Zhang1, Xin He2, Wei Chen1
1Department of Immunology, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Huanggu District, Shenyang, Liaoning 110847, China.
Immunology letters
|July 3, 2024
概括
维生素D3 (VitD3) 通过平衡免疫细胞,有助于减少自身免疫性甲状腺炎 (AITD). 它调节Th17/Treg细胞群,并准YAP/JAK/STAT通路,为AITD提供潜在的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 自身免疫性甲状腺炎 (AITD) 是一种特定器官的自身免疫性疾病.
- 维生素D (VitD) 缺乏与AITD风险增加有关.
- 维特D3对Th17/Treg细胞和AITD中的分子机制的具体影响尚不清楚.
研究的目的:
- 研究维生素D3 (VitD3) 对免疫细胞子集,特别是Th17和Treg细胞的影响.
- 阐明VitD3影响实验性自身免疫甲状腺炎 (EAT) 的潜在分子机制.
主要方法:
- 一个实验性自身免疫甲状腺炎 (EAT) 鼠标模型被诱导.
- 评估了甲状腺损伤,血清激素水平,自身抗体和细胞因子水平.
- 使用流细胞计和免疫组织化学分析Th17/Treg细胞群.
- 进行了细胞活力和亡试验.
- 研究了YAP和JAK/STAT路径的作用.
主要成果:
- 在EAT小鼠中,服用VitD3可降低甲状腺损伤,炎症和自身抗体水平.
- 在甲状腺组织和脊髓细胞中,VitD3降低了Th17细胞频率,增加了Treg细胞频率.
- VitD3抑制了炎症性细胞因子的产生,并调节了Treg细胞的分化,活力和亡.
- VitD3提高了YAP表达的调节,并激活了JAK/STAT通路.
- YAP 枯竭逆转了 VitD3 对 Treg 细胞的影响.
结论:
- 维生素D3通过调节Th17/Treg细胞平衡来减轻自身免疫性甲状腺炎 (AITD).
- 该机制涉及对YAP/JAK1/STAT1轴的调节.
- 维特D3通过恢复免疫平衡来证明AITD的治疗潜力.
相关概念视频
T Cell Types and Functions
996
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
996
The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
Autoimmune Disorders
409
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
409
Synthesis and Regulation of Thyroid Hormones
4.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.5K
Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
TGF - β Signaling Pathway
7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K

