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从共同点中成长:非结核菌和支气管切除
Eva Van Braeckel1,2,3, Cédric Bosteels4,2,3
1Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium Eva.vanbraeckel@ugent.be.
非结核性真菌菌 (NTM) 和支气管切除与NTM肺病 (NTM-PD) 密切相关,需要综合诊断和治疗. 目前的疗法是漫长和不理想的,需要个性化,宿主导的策略.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 支气管切除症和非结核性真菌菌 (NTM) 具有复杂的关系,NTM可能导致或导致支气管切除性疾病.
- 非结核菌肺病 (NTM-PD) 越来越多地被识别为患有支气管切除症的患者.
研究的目的:
- 在支气管病的背景下,审查NTM-PD的诊断方法,风险因素和治疗策略.
- 突出管理这种交织的状况所面临的挑战和未来的方向.
主要方法:
- 这篇叙述性综述综合了关于支气管切除症和NTM-PD的诊断和管理的当前文献.
- 它检查了临床,放射学和微生物学的诊断标准.
- 它讨论了当前和新兴的治疗策略,包括抗微生物和宿主导疗法.
主要成果:
- 诊断NTM-PD需要综合临床,放射学和微生物学的发现.
- 菌复合体和Mycobacterium abscessus是常见的NTM物种在支气管切除.
- 目前针对NTM-PD的基于指导方针的治疗方法是漫长的,并且往往产生不满意的结果.
- 新的治疗策略,包括无里芬素治疗方案,克洛法齐明,吸入抗生素和宿主导疗法正在调查中.
结论:
- 在支气管切除中有效管理NTM-PD需要采用多学科,个性化的方法.
- 优化支持性护理,病原体导向和宿主导向策略至关重要.
- 对宿主 - 菌根菌相互作用的进一步研究对于开发改进的治疗策略至关重要.
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