成年人注意力缺陷/多动性障碍中小脑网络的改变
Salla Parkkinen1, Joaquim Radua1, Derek S Andrews1
1From the Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Andrews, Murphy, Dell'Acqua, Parlatini); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Murphy, Dell'Acqua, Parlatini); the Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain (Radua); the Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA, USA (Andrews); the Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Dell'Acqua); the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK (Dell'Acqua); the School of Psychology, University of Southampton, Southampton, UK (Parlatini); the Solent NHS Trust, Southampton, UK (Parlatini).
成年ADHD可能涉及小脑网络差异. 这项研究发现,在ADHD的成年人中,中小脑脚 (MCP) 的白质微观结构发生了变化,小脑底脚 (ICP) 的辐射扩散率增加.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种神经发育状况,持续到成年.
- 大脑小骨 (中,上,下) 与ADHD病理生理学有关,但仍未得到充分探索.
- 研究小脑脚可能会揭示对成人多动症的新见解.
研究的目的:
- 为了研究小脑在成年ADHD中的作用.
- 探索ADHD和对照成年人之间小脑脚内管道指标的差异.
- 在ADHD中检查通道指标和临床/神经心理资料之间的关联.
主要方法:
- 扩散权重球形解卷曲通道学被用于分析ADHD和对照的成年男性大脑小脚.
- 在ADHD和对照组之间,以及在治疗响应者和不响应者之间,对管道指标进行了比较.
- 分析了管道指标和临床神经心理资料之间的关联.
主要成果:
- 与对照人群相比,患有ADHD的成年人表现出中脑小脚 (MCP) 中断微分异构 (FA) 和阻碍调制定向异构 (HMOA) 的降低.
- 在ADHD组中观察到右下小脑脚 (ICP) 的辐射扩散率 (RD) 增加.
- 在治疗响应群和不响应群中存在MCP变化,而ICP RD差异仅在响应群中显著.
结论:
- 小脑网络,特别是MCP,在成年ADHD病理生理学中发挥作用.
- 研究结果表明,小脑通路的潜在微观结构变化有助于ADHD.
- 需要进一步的研究来探索性别和发育差异.
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