六个月后COVID症状风险的时间变化:基于全国人口的队列研究
Anne Pastorello1, Laurence Meyer1,2, Joël Coste3
1Paris-Saclay University, University of Versailles Saint-Quentin-en-Yvelines, National Institute of Health and Medical Research, Center for Epidemiology and Population Health, Le Kremlin-Bicêtre, France.
American journal of epidemiology
|July 3, 2024
概括
与第二波相比,在法国的第一波流行病期间,患COVID后症状的风险更高. 这一发现出现在广泛的变种和疫苗可用性之前,突显了早期的流行病风险.
科学领域:
- 流行病学 流行病学
- 传染病的动态传染病的动态.
背景情况:
- 在大流行期间,COVID后症状风险的演变仍然不清楚,特别是在严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 变种和广泛的疫苗可用性出现之前.
- 了解COVID后条件的时间趋势对于公共卫生干预和资源分配至关重要.
研究的目的:
- 为了比较法国第一个和第二次COVID-19浪潮之间的六个月后COVID症状和相关风险因素的风险.
- 为了调查影响COVID后症状发展的因素,在早期的流行病时期.
主要方法:
- 在15岁及以上的全国人口群体中使用了修改后的Poisson回归.
- 使用非响应权重和多重归算来解决缺失的数据.
- 法国COVID-19第一波 (2020年3月至5月) 和第二波 (2020年9月至11月) 之间的COVID后症状风险比较.
主要成果:
- 在第一波 (14.6%) 与第二波 (7.0%) 相比,六个月后COVID症状的风险显著更高,调整后的相对风险为1.36.
- 后COVID症状的危险因素包括基线的身体和精神状况,以及急性症状的数量.
- 在第一波疫情中,女性和受教育程度较低的人群的风险更高.
结论:
- 在法国的流行病最初阶段 (第一波) 患上六个月后COVID症状的风险明显高于随后的阶段 (第二波).
- 这些观察到的差异早于SARS-CoV-2变种的传播和疫苗的可用性,强调了早期流行病状况的影响.
- 基线健康状况和人口因素显著影响了持续后COVID症状的风险.
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