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非侵入性诊断方法,通过分子向光成像剂客观测量嗅觉和诊断气味障碍

Dauren Adilbay^1,2, Junior Gonzales¹, Marianna Zazhytska³

¹Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

|July 3, 2024

概括

一个新的光探测器,Tsp1a-IR800_P,可以通过向道1.7.7来非侵入性检测气味损失. 该工具提供了一种定量方法来诊断嗅觉功能障碍,这对于2019年冠状病毒疾病等疾病至关重要.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
医学诊断医学诊断医学诊断

背景情况:

嗅觉功能障碍,特别是嗅觉丧失,是2019年冠状病毒疾病等疾病的重要症状.
目前用于诊断嗅觉丧失的方法往往是主观的,缺乏定量评估.
对于客观地识别和量化嗅觉缺陷的非侵入性工具有着未得到满足的需求.

研究的目的:

研究一种新型光探针Tsp1a-IR800_P的潜力,用于对嗅觉丧失进行非侵入性诊断.
评估道1.7表达和嗅觉功能障碍之间的相关性.
建立一种定量方法,用于在临床前和临床环境中评估嗅觉丧失.

主要方法:

使用了一种新的光探针,TSP1a-IR800_P,旨在准通道1.7.
研究了嗅觉上皮的转录和蛋白质水平上的通道1.7的表达水平.
在活体动物中评估了Tsp1a-IR800_P的光排放,并将其与嗅觉功能相关联.

主要成果:

在与嗅觉丧失相关的条件下,确定了通道1.7表达的下调,包括2019年新冠肺炎和慢性炎症.
在活体动物中,较低的Tsp1a-IR800_P光排放和气味丧失的存在之间显示出显著的相关性.
展示了Tsp1a-IR800_P作为嗅觉功能的半定量评估的潜在工具.

结论:

Tsp1a-IR800_P探针显示出作为客观诊断气味丧失的非侵入性工具的承诺.
这种方法可以显著提高与嗅觉相关的临床前和临床研究.
客观诊断嗅觉丧失可以加速开发有效的治疗干预措施.

关键词:

在 COVID-19 疫情中,厌食症是一种厌食症.光成像成像技术的使用.嗅觉嗅觉是一种嗅觉.这是一个光学模型.气味味道味道味道味道

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相关概念视频

Immunofluorescence Microscopy

Immunofluorescence Microscopy

A fluorescence microscope uses fluorescent chromophores called fluorochromes, which can absorb energy from a light source and then emit this energy as visible light. Fluorochromes include naturally fluorescent substances (such as chlorophylls) and fluorescent stains that are added to the specimen to create contrast. Dyes such as Texas red and FITC are examples of fluorochromes. Other examples include the nucleic acid dyes 4’,6’-diamidino-2-phenylindole (DAPI), and acridine orange.