纳姆普特的日常节奏取决于性别和体重
I V Frielitz-Wagner1, J Mattutat2, F S Frielitz2
1Department of Paediatrics, Medical Faculty, UKSH, University of Lübeck, Lübeck, Germany; University of Leipzig, Medical Faculty, Leipzig University Medical Center, Department of Women´s and Child Health, Hospital for Children and Adolescents, Leipzig, Germany.
Obesity research & clinical practice
|July 3, 2024
概括
尼古丁胺胺酸基转移酶 (Nampt) 呈现昼间节律,受性别和体重的影响. 这种节奏在肥胖的男性中受到干扰,在女性中观察到更高的Nampt幅度.
科学领域:
- 代谢研究的研究.
- 内分泌学 在内分泌学.
- 时间生物学 时间生物学
背景情况:
- 尼古丁胺胺酸基转移酶 (Nampt) 是一种与肥胖,2型糖尿病和炎症相关的脂肪基因.
- 以前的研究表明,瘦身男性的Nampt有一个白天的节奏,下午达到峰值.
- 性别和体重对南普特日间活动模式的影响仍然未被探索.
研究的目的:
- 为了研究与性别和体重相关的Nampt血清水平的日间节奏.
- 评估饮食,口服葡萄糖耐受性测试 (OGTT) 和体育炼对Nampt度的影响.
- 为了确定纳姆普特水平和其他荷尔蒙,实验室和人类参数之间的相关性.
主要方法:
- 在24小时内测量Nampt血清水平在健康的正常体重和肥胖个体中.
- 评估了标准化饮食,OGTT和体育炼对Nampt水平的影响.
- 通过各种生理和生化标志物进行相关性分析.
主要成果:
- 纳普特表现出白天节律,在下午早些时候达到顶峰,在除肥胖男性以外的所有群体中都显著.
- 与男性相比,女性的Nampt幅度显著更高.
- 运动和OGTT显著改变了Nampt水平,而饮食没有.
结论:
- 观察到南普特振幅和变量系数的性别特异差异,女性的值更高.
- 在瘦个体中,Nampt的昼夜节律在两性之间是一致的,但在肥胖男性中受到干扰.
- 这些发现突出了性别和肥胖对南普特日间调节的影响.
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