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使用结构性和功能性MRI对由于轻度COVID-19而导致持续嗅觉功能障碍的患者进行比较成像研究
David Dylan García-Meléndez1, Raquel Moreno Presa1, Pilar Quintana Castro1
1University Hospital of Toledo, Av. del Río Guadiana, 45007 Toledo, Spain.
Medicina clinica
|July 3, 2024
概括
在轻度的COVID-19病例中研究了COVID后持续的嗅觉功能障碍. 功能性核磁共振扫描显示,尽管大脑形态正常,但与对照组不同,患者体内内皮层没有激活.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 持续的嗅觉功能障碍是COVID-19的常见后果,病理生理学不清楚.
- 神经成像研究对于了解COVID后嗅觉丧失的潜在机制至关重要.
研究的目的:
- 为了研究神经成像相关的持续性嗅觉功能障碍在轻度COVID-19后.
- 为了比较COVID后气味丧失患者的嗅球和大脑活动,与健康对照对比.
主要方法:
- 评估了8名患有超过1个月的嗅觉功能障碍后轻度COVID-19和2名对照组的患者队列.
- 嗅觉功能使用Sniffin' Sticks嗅觉测试进行了评估.
- 通过MRI和功能性MRI (fMRI) 进行了大脑和嗅觉球形态学.
主要成果:
- 在患者和对照组之间没有观察到大脑或嗅觉球的形态差异.
- 功能性MRI没有显示患者体内内皮层激活,与对照组相比.
- 在患者和对照中,二次嗅觉区域的激活有所不同:轨道前 (25%与100%),基底 (25%与50%),胰岛 (38%与0%).
结论:
- 后COVID嗅觉功能障碍与形态大脑变化无关.
- 功能性MRI显示,在COVID后持续嗅觉丧失的患者中,内腔皮层激活受损.
- 二次嗅觉区域的激活模式改变可能导致COVID-19后的嗅觉缺陷.
相关概念视频
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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...