铺平一条道路,在心脏关护理中实现公平
1Institute for Health Equity Research, Department of Population Health, Icahn School of Medicine at Mount Sinai, New York, NY; Barbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Seminars in nephrology
|July 3, 2024
概括
心脏综合征涉及心脏和脏疾病之间的复杂相互作用. 实现健康公平需要解决糖尿病和高血压等疾病的治疗机会差异.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 健康 公平 卫生 公平
背景情况:
- 心脏病综合征是由心血管和脏疾病的相互作用引起的,受糖尿病,心力衰竭和高血压等疾病的影响.
- 对于心血管,和代谢 (CKM) 疾病,在获得和利用疾病修饰疗法,如-葡萄糖共运输体2抑制剂方面存在显著差异.
- 健康的社会决定因素不平等地影响心脏脏风险因素,包括心力衰竭,糖尿病和慢性病.
研究的目的:
- 审查高血压,2型糖尿病和心力衰竭的负担和治疗方面的不平等.
- 检查使用关键疾病修饰疗法对CKM疾病的差异.
- 确定多层次的障碍,并提出解决方案,以实现在CKM疾病管理中更大的药物公平.
主要方法:
- 文献综述综合证据关于CKM疾病的健康差异.
- 分析现有关于治疗准入和利用的数据.
- 检查健康的社会决定因素在心脏和脏差异中的作用.
主要成果:
- 在高血压,2型糖尿病和心力衰竭的流行和管理方面,不平等仍然存在.
- 显而易见的差异是对CKM条件的关键疾病修饰剂的吸收.
- 多层次的障碍,包括患者,提供者和系统层面的因素,阻碍了公平获得治疗的机会.
结论:
- 实现心脏脏健康公平需要一个范式的转变,正如2023年美国心脏协会的建议所强调的那样.
- 解决不平等的健康社会决定因素对于缓解心脏脏健康差异至关重要.
- 针对患者,提供者和卫生系统量身定制的多部门干预措施对于促进药物公平至关重要.
相关概念视频
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
419
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
419
Renal Failure: Dose Adjustments
79
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
79
Renal Drug Clearance: Overview
180
Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
180
Renal Drug Excretion: Overview
144
As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
144
Renal Regulation of Acid-Base Balance
388
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
388
Renal Clearance
870
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
870


