扩散型组织学对所有Siewert类型的胃食道腺癌具有预后作用
Kelly M Mahuron1, Kevin M Sullivan1, Matthew C Hernandez1
1Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Journal of gastric cancer
|July 3, 2024
概括
胃食道结腺癌 (GEJA) 的扩散型组织学与更高的复发率和更差的存活率有关,无论瘤的位置如何. 组织病理学对于指导GEJA治疗策略至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 瘤病理学 瘤病理学
背景情况:
- 胃食道结腺癌 (GEJA) 的最佳治疗方法仍在争论中.
- 组织学亚型显著影响癌症行为和治疗反应.
研究的目的:
- 评估局部发达GEJA的治疗模式和结果.
- 评估组织学类型对患者结果的影响.
主要方法:
- 一个回顾性队列研究,对58名经过手术的局部发达GEJA患者进行了回顾性队列研究 (2010-2020).
- 术后治疗方法,临床病理学,手术和生存数据的分析.
- 用于瘤类型的Siewert和Lauren分类.
主要成果:
- 与肠道类型相比,扩散型组织学 (36%) 与腹腔内复发的增加 (P=0.03) 和整体存活率的降低 (HR 2.33,P=0.02) 相关.
- 50%的患者出现了复发,平均整体存活时间为50.5个月.
- 所有患者都接受了新辅助疗法 (72%的化疗, 41%的化疗).
结论:
- 扩散型组织学在西沃特分类中同样普遍,预测GEJA的结果会更差.
- 组织病理学评估对于量身定制GEJA多模式治疗策略至关重要,除了瘤的位置.
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