肌肉间脂肪组织的积累与健康个体的较高组织有关
Lale A Ertuglu1, Melis Sahinoz1, Aseel Alsouqi2
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Physiological reports
|July 3, 2024
概括
腿部组织中的高与健康成年人的肌肉间脂肪组织 (IMAT) 增加有关. 这种关联,特别是在皮肤中,可能受到像CRP和IL-6这样的全身炎症标志物的影响.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
背景情况:
- 高组织和肌肉间脂肪组织 (IMAT) 与衰老,2型糖尿病和慢性病有关.
- 了解组织和IMAT之间的关系对于代谢健康研究至关重要.
研究的目的:
- 为了研究下肢组织积和IMAT量之间的关联.
- 为了确定系统性炎症调解剂和脂肪细胞因子是否有助于这种关联.
主要方法:
- 牛犊的 (Na-MRI) 和质子 (1H-MRI) 影像被用来测量83名健康个体的组织含量和IMAT百分比.
- 胰岛素敏感性通过使用高胰岛素-高血糖的葡萄糖处理率 (GDR) 来评估.
主要成果:
- 增加肌肉和皮肤组织的含量与更高的IMAT数量有显著的关联,即使在调整年龄,性别,BMI,GDR,阿迪波涅丁和高灵敏性C反应蛋白之后.
- 皮肤与IMAT仅在男性中显著相关.
- 皮肤和IMAT之间的关联被高灵敏度C反应蛋白和INTL-6的较高水平放大.
结论:
- 腿部肌肉和皮肤与健康个体的IMAT量有关.
- 系统性炎症可能会调解皮肤和IMAT之间的关系.
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