"-"饮食的代谢后果明显受到遗传多样性的影响
Senthil Thillainadesan1,2,3, Aaron Lambert1,4, Kristen C Cooke1,4
1Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
International journal of obesity (2005)
|July 3, 2024
概括
减肥可以改善肥胖并发症,但遗传多样性会影响代谢恢复. 体重循环是有害的,导致高胰岛素血症和胰岛素分泌量升高,在体重恢复后没有持久的益处.
科学领域:
- 代谢健康 代谢健康
- 肥胖问题研究研究
- 遗传学 是一个遗传学.
背景情况:
- 肥胖并发症可以通过减肥来改善.
- 体重减轻后胰岛素抵抗的持续性和重量恢复 (体重循环) 对代谢健康的影响仍然不清楚.
- 遗传背景对体重循环结果的影响是未经记录的.
研究的目的:
- 研究减肥和体重循环对代谢结果的影响.
- 澄清遗传学在对体重循环的代谢反应中的作用.
主要方法:
- 小鼠 (C57BL/6J和基因多样化的DOz) 交替吃高脂肪饮食和饮食8周间隔.
- 评估了代谢参数,包括身体组成,葡萄糖耐受性,胰腺β细胞活性,肝脂和脂肪组织的胰岛素敏感性.
主要成果:
- 在减肥后,C57BL/6J小鼠表现出快速的代谢正常化,与DOz小鼠不同,它们保持了更高的脂肪质量和更高可变性的胰岛素水平.
- 在C57BL/6J小鼠中,体重循环导致血中的胰岛素水平较高,相比于最初接受高脂肪饮食的对照组.
- 所有体重循环的动物都表现出增加的β细胞活性,尽管脂肪质量和葡萄糖耐受性相似.
结论:
- 肥胖C57BL/6J小鼠的代谢结果在减肥后恢复到基线,但遗传多样性显著改变了这种反应.
- 体重减轻在重量恢复后没有持久的好处;体重循环是有害的,与高胰岛素血症和基本胰岛素分泌量增加有关.
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