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Updated: Jun 22, 2025

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
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在胚胎干细胞中的CRISPR/Cas9屏幕显示,Mdm2调节全能性退出

Chen Gao1,2, Xin Gao1,3, Fei Gao1,3

  • 1State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.

Communications biology
|July 3, 2024
PubMed
概括

研究人员确定了早期胚胎发育的关键调节器,揭示了Mdm2作为一个关键的负调节器. 扰乱Mdm2会增加2细胞类细胞 (2CLCs) 的比例,影响细胞命运和表观遗传修饰.

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Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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