在Omicron疫情期间喘和COVID-19严重程度之间的关联:使用真实世界的数据进行了回顾性队列研究
Huwen Wang1, Xiaoting Jiang1, Kate Ching Ching Chan2
1School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
BMC infectious diseases
|July 3, 2024
概括
喘没有增加COVID-19的严重程度或死亡风险在Omicron感染. 这项研究发现喘患者的严重结局率较低,即使没有完全接种疫苗.
科学领域:
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
- 流行病学 流行病学
背景情况:
- 关于喘和COVID-19结果的现有研究表明存在不一致.
- 喘对SARS-CoV-2 Omicron感染的严重结果的影响需要进一步调查.
研究的目的:
- 为了检查喘和COVID-19患者感染Omicron变种的严重临床结果之间的关联.
- 评估喘患者的死亡风险和疾病严重程度,与在Omicron波期间的非喘患者相比.
主要方法:
- 一个回顾性队列研究使用了倾向性得分匹配.
- 在奥米克朗占主导地位期间 (2022年1月至11月) 在香港确诊的住院COVID-19患者.
- 定义的严重结果是ICU入院,住院死亡,或两者的组合.
主要成果:
- 在一个匹配的队列中,喘患者 (n=1,290) 与非喘患者 (15.3%和17.2%) 相比,死亡率 (12.2%) 和复合严重结局 (13.6%) 较低.
- 调整后的危险比率表明喘患者的死亡风险降低 (0.775) 和综合结果 (0.770).
- 这种保护性关联在老年人群和女性群体中更为明显,不论疫苗接种情况如何.
结论:
- 在Omicron变种激增期间,喘并未被确定为严重COVID-19结果的危险因素.
- 现实世界的数据表明,喘可能会对严重疾病产生保护作用,即使在部分接种疫苗的人身上也是如此.
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