第四阶段子宫内膜异位症妇女的凝血状态
Lu Wang1, Jingxian Ling1, Xianghong Zhu1
1Department of Obstetrics and Gynecology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China.
BMC women's health
|July 3, 2024
概括
这项研究发现,炎症标志物与IV期子宫内膜异位症的凝血因子相关. 将它们与CA125和CA199结合起来,可以更好地识别严重的子宫内膜异位症.
科学领域:
- 妇科瘤学 妇科瘤学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 子宫内膜异位症是一种与高凝血状态相关的全身性炎症性疾病.
- 目前的分期将子宫内膜异位症分为四个阶段 (I-IV).
- 第四期子宫内膜异位症代表严重的疾病,通常具有全身影响.
研究的目的:
- 调查IV期子宫内膜异位症炎症标志物和凝血因子之间的相关性.
- 评估这些标志物的诊断价值,以识别严重的子宫内膜异位症.
主要方法:
- 追溯病例控制研究涉及171名IV期子宫内膜异位症患者和184名对照.
- 统计分析包括曼-惠特尼U,奇平方和斯皮尔曼相关性测试.
- 用接收器操作特征 (ROC) 曲线分析来评估诊断性能.
主要成果:
- 第四期子宫内膜异位症患者的活性部分血栓形成时间 (APTT) 减少,纤维素原 (FIB) 和中性粒细胞与淋巴细胞比率 (NLR) 增加.
- APTT与NLR负相关,而FIB与NLR正相关.
- 结合FIB,CA125和CA199的测试表明,用于识别IV期子宫内膜异位症,诊断准确度最高 (AUC为0.895).
结论:
- 炎症标志物与IV期子宫内膜异位症的凝血参数 (APTT,FIB) 有显著的相关性.
- 将凝血因子与瘤标志物CA125和CA199结合起来,可提高识别IV期子宫内膜异位症的可靠性.
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