酸盐限制增强了Ustilago trichophora含有丰富的糖蜜的酸生产
Luca Antonia Grebe1, Philipp Georg Lichtenberg1, Katharina Hürter1
1AVT-Biochemical Engineering, RWTH Aachen University, Forckenbeckstraße 51, 52074, Aachen, Germany.
Biotechnology for biofuels and bioproducts
|July 3, 2024
概括
酸盐的限制,而不是气,显著提高了从Ustilago trichophora使用的糖蜜中产生酸的产量. 这一发现使得从农业残留物制造具有成本效益的生物化学制造成为可能.
科学领域:
- 生物技术是生物技术.
- 工业微生物学 工业微生物学
- 可持续化学 可持续化学
背景情况:
- 用生物基替代品取代石化,需要有效发酵各种原料.
- 乌斯蒂拉吉纳属微生物可以产生有价值的化合物,但与像糖蜜这样的高原料作斗争.
- 酸是一种多用途的平台化学物质,在食品,制药和聚合物中具有应用.
研究的目的:
- 开发一种选方法,用于评估微生物生产中的复杂原料.
- 用Ustilago trichophora在糖蜜上确定酸生产的最佳条件.
- 克服阻碍在生物化学合成中使用农业残留物的局限性.
主要方法:
- 开发了一种微升尺度的查方法,在线进行呼吸监测.
- 在定义的介质上研究了,,硫酸盐和的限制.
- 在以糖蜜为基础的介质中评估基质同化和产品形成.
主要成果:
- 在和酸限制下,酸生产取得了成功.
- 在限制条件下,Ustilago trichophora显示了元素组成的适应性变化.
- 与限制相比,酸限制增加了65%的酸产量.
- 糖蜜对和的同化程度有限 (分别为25%和50%).
结论:
- 酸盐限制优于酸盐限制,可以增强从糖蜜中产生酸的产量.
- 这一发现有助于将糖蜜作为可持续且具有成本效益的原料.
- 从农业副产品中制造生物基平台化学品的新途径.
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