相关实验视频

Updated: May 13, 2026

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

在CAR-T细胞治疗后评估费里丁的诊断陷:了解效应

Roa Harb¹, Tatiana C Coverdell¹, Haneen Shalabi²

¹Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

Pediatric blood & cancer

|July 4, 2024

概括

效应可以导致由于过多的分析物导致错误的低费里测试结果. 这一案例凸显了临床医生和实验室之间关于异常费里测量的认识和沟通的需要.

科学领域:

临床化学临床化学
免疫化学免疫化学
血液学血液学血液学

背景情况:

效应是一种免疫试验干扰,导致高分析度的错误低结果.
这种现象在临床上被低估了,尽管它可能对患者的诊断和管理产生影响.
精确的费里丁测量对于诊断诸如血细胞淋巴细胞瘤样综合征等疾病至关重要.

研究的目的:

为了描述由于效应而导致的显著费里丁免疫测试干扰的情况.
强调效应在费里测试中的临床影响.
促进有关免疫测试干扰的认识和沟通.

主要方法:

一个27岁的女性病例研究,患有免疫效应细胞相关的血细胞性淋巴细胞类似综合征.
在内部测试和参考实验室之间比较费里丁免疫测试结果.
对不一致的费里丁测量进行稀释效应的评估.

主要成果:

与内部结果相比,参考实验室的费里水平比内部结果低1000倍以上.
样品的稀释纠正了在参考实验室观察到的虚假低费里丁测量值.
这种差异突显了这个患者的费里丁测定中效应的存在.

结论:

效应可能导致严重低估的费里水平,可能误导临床决策.
临床护理提供者必须警预期和报告的费里丁值之间的差异.
临床医生和实验室之间的快速沟通对于识别和解决像效应这样的免疫测试干扰至关重要.

关键词:

细胞因子释放综合征细胞因子释放综合征费里丁是一种铁素.子效应是一个子效应.免疫效应细胞相关的血细胞性淋巴组织细胞瘤样综合征.免疫测试干扰干扰

更多相关视频

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

相关概念视频

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...