新生儿出生缺陷风险增加的卵细胞中的光滑内质网膜聚合物:元分析
Rui Long1, Meng Wang1, Qiyu Yang2
1Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Acta obstetricia et gynecologica Scandinavica
|July 4, 2024
概括
在试管婴儿周期中,光滑的内质网膜聚合物 (SERa+) 与儿童出生缺陷的风险更高有关. 这一发现支持在辅助生殖中仔细选择胚胎,以改善新生儿的结果.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 新生儿结局的结果.
背景情况:
- 顺的内等质网膜聚合物 (SERa+) 与医疗辅助生殖的较差结果有关.
- SERa+与新生儿结局,特别是出生缺陷之间的联系需要进一步调查.
研究的目的:
- 对SERA+与出生缺陷风险之间的关系进行全面的元分析.
- 为试管婴儿临床实践和胚胎选择提供基于证据的指导.
主要方法:
- 在多个数据库 (PubMed,Embase,Cochrane,Web of Science,CNKI,Wan Fang) 进行了系统的文献搜索,直到2023年7月.
- 风险比率 (RR) 和95%置信区间 (CI) 使用固定效应模型进行计算.
- 分别使用I2统计和漏斗图表来评估异质性和出版偏差. 这项研究已登记在PROSPERO (CRD42022313387) 上.
主要成果:
- 在已识别的122项研究中,有14项符合分析的纳入标准.
- 来自SERA+周期的儿童的出生缺陷风险显著增加 (RR=2.17,95%CI 1.24-3.81).
- 在子组分析中,SERA+卵子细胞与兄弟SERA-卵子细胞相比,也显示出出生缺陷的风险显著增加 (RR=3.53,95%CI 1.21-10.24).
结论:
- 与SERA-对应物相比,SERA+周期和卵细胞与重大出生缺陷的潜在风险增加有关.
- 这些发现提供了证据,以支持临床医生和胚胎学家在试管婴儿指导和胚胎选择策略.
- 进一步的研究可能会阐明这种关联背后的机制,并完善临床方案.
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