根据他类药物的使用情况对细颗粒物 (PM2.5) 和心血管死亡率之间的关联进行影响修改
Li Bai1, Jeffrey C Kwong1,2,3,4, Jay S Kaufman5
1Primary Care & Population Health Research Program, ICES, Toronto, ON, Canada.
International journal of epidemiology
|July 4, 2024
概括
长期暴露于细颗粒物 (PM2.5) 增加了心血管死亡风险,特别是在不使用他类药物的人群中. 立方体使用可能会对与PM2.5相关的心血管和冠状动脉心脏病死亡提供一定程度的保护.
科学领域:
- 环境健康 环境健康
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 细颗粒物 (PM2.5) 暴露与心血管死亡率的增加有关.
- 心血管药物使用,特别是他类药物对这种关联的影响需要进一步调查.
研究的目的:
- 确定他类药物的使用是否改变了长期暴露于PM2.5和心血管原因,冠心病 (CHD) 和中风死亡率之间的关联.
- 量化效果修改在乘法和加法两种尺度上.
主要方法:
- 这是一项对加拿大安大略省120万老年人 (2000年至2018年) 进行的嵌套病例控制研究.
- 使用发病率密度抽样,将死亡病例 (心血管,心脏病,中风) 个别匹配至多30个对照组.
- 条件后勤回归模型用于估计赔率比率 (ORs) 和评估效果修改 (ORs的比率,RERI).
主要成果:
- 暴露于PM2.5显著增加了心血管,心脏病和中风死亡率的风险.
- 与使用他类药物相比,非使用他类药物的PM2.5和死亡率之间的关联在非使用他类药物的患者中更强.
- 在他类药物使用者中,部分遵守与与PM2.5相关的死亡风险比完全遵守更高.
结论:
- 慢性PM2.5暴露对心血管和心血管疾病死亡率的有害影响在不使用他类药物的人群中更为明显.
- 达丁类药物的使用似乎减轻了与长期PM2.5暴露相关的死亡风险.
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