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制造一种病原体? 评估原生动物掠食对Serratia marcescens病毒性进化的影响

Heather A Hopkins^1,2, Christian Lopezguerra^1,2, Meng-Jia Lau¹

¹Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, USA.

Genome biology and evolution

|July 4, 2024

概括

亲生虫的掠食驱动了机会性病原体的毒性演变,例如Serratia marcescens. 环境细菌进化以抵抗捕食者也保持或增加了他们的致病特征.

科学领域:

微生物学微生物学
进化生物学进化生物学
病变的发生和发病.

背景情况:

机会性病原体是环境微生物,在某些条件下可以引起疾病.
这些病原体中毒性的演变尚未完全理解,假设表明特征以其他目的进化.
亲生虫捕食是一种被提议的选择性压力,可能驱动细菌毒性进化.

研究的目的:

调查原生虫捕食对Serratia marcescens的毒性和适应性的影响.
探索环境选择性压力在细菌毒性的进化中的作用.

主要方法:

在60天的时间里,在前列动物捕食者Tetrahymena thermophila的存在和缺席下,Serratia marcescens的实验进化.
全基因组猎枪测序用于识别遗传变化.
现型检测评估病毒毒性,生物膜形成,生长和牧场耐药性.

主要成果:

在与毒性相关的基因中观察到显著的并行进化,当S. marcescens与捕食者一起进化时.
在捕食者的存在下,进化维持了细菌的毒性.
没有捕食者的进化导致了衰弱的毒性,发现了毒性,生物膜形成,生长和放牧耐药性之间的相关性.

结论:

原生虫的掠食行为作为一种选择性压力,维持或增强细菌的毒性.
机会性病原体的毒性相关特征可以通过适应环境挑战而演变,例如避免掠食.

关键词:

细菌细菌细菌是一种细菌.进化进化演化演化演化演化这种情况是什么? exaptation exaptation.机会主义病原体的病原体.捕食掠食掠食掠食毒性毒性是一种毒性.

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