CO2对神经血管合的年龄依赖性的影响
Aaron Davies1, Dewarkar Gurung1, Kannaphob Ladthavorlaphatt1
1Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
衰老在不同的二氧化碳 (CO2) 水平下不同影响神经血管合 (NVC). 超和低都抑制了跨年龄组的NVC反应,中年成人在超下表现出独特的反应.
科学领域:
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
- 老年学是一门学科.
背景情况:
- 之前的研究表明,衰老对神经血管合 (NVC) 的影响不一致.
- 二氧化碳 (CO2) 影响大脑血液速度 (CBv) 和NVC,但在不同的CO2条件下,与年龄相关的NVC变化仍然不清楚.
研究的目的:
- 为了研究衰老对不同CO2状态 (poikilocapnia,hypercapnia,hypocapnia) 的NVC的影响.
- 检查与年龄和二氧化碳水平相关的认知任务 (视觉空间和注意力) 中的NVC反应.
主要方法:
- 78名参与者 (18-78岁) 进行了持续的CBv监测,使用中 (MCA) 和后 (PCA) 大脑动脉的横多普勒测试.
- 测量包括血压,潮尾CO2和心率在控制的高头 (5%CO2) 和低头 (节奏过度呼吸) 期间.
- 通过比较不同CO2条件和年龄组 (≤30,31-60,>60岁) 的视觉空间和注意力任务中的CBv变化来评估NVC.
主要成果:
- 在poikilocapnia中,年轻的成年人在视觉空间任务中表现出比老年人更低的NVC反应.
- 在高头期间,年轻人和中年人群与老年人相比,NVC反应减少.
- 在低头皮症期间,老年人和中年人群都表现出与年轻人相比,NVC反应的增强.
- 在高头和低头期间,NVC抑制的程度与基线相比,在各年龄组之间没有显著差异.
- 中年成人在高头症下与低头症相比,显示出明显的NVC反应.
结论:
- 在改变的二氧化碳条件下,衰老会影响神经血管合反应.
- 超和低都显著抑制了NVC反应.
- 中年成年人表现出独特的NVC反应模式,在超缩和低缩状态之间存在差异.
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