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神经血管合功能障碍与 Presbycusis 的认知障碍相关

Chunhua Xing¹, Jianhua Feng², Jun Yao¹

¹Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.

Brain communications

|July 4, 2024

概括

神经血管合,对于大脑功能至关重要,在老年听 (与年龄相关的听力损失) 中受损,影响认知. 区域分析揭示了与认知衰退相关的特定脑电路功能障碍.

科学领域:

神经科学是一个神经科学.
听力学听力学是指听力学.
医疗成像医学成像

背景情况:

听力衰竭 (与年龄相关的听力损失) 的神经病理学是不太了解的.
认知障碍是常见的伴随性疾病中presbycusis患者.
神经血管合链接大脑活动和血液流动,对认知功能至关重要.

研究的目的:

调查神经血管合机制与 Presbycusis 的认知障碍相关.
为了比较presbycusis患者和健康对照者之间的全球和区域神经血管合.
分析改变的神经血管合和认知表现之间的关系.

主要方法:

使用大脑血流和BOLD衍生的定量图 (ALFF,fALFF,ReHo,DC) 之间的相关系数评估神经血管合.
计算了四个神经血管合指标:CBF-ALFF,CBF-fALFF,CBF-ReHo和CBF-DC.
在全球和区域范围内比较了长和对照组之间的指标,并与神经心理学尺度相关联.

主要成果:

全球神经血管合与对照组相比,大脑缩组显著减少,与认知水平相关.
区域分析显示三个大脑区域的显著升高和一个下降,所有这些都在帕佩兹电路内.
区域神经血管合提供了比全球措施更详细的见解.

结论:

神经血管合在长中受损,导致认知缺陷.
帕佩兹电路神经血管合中的功能障碍与与年龄有关的听力损失的认知和情绪障碍有关.

关键词:

血液中的氧气水平依赖于血液中的氧气水平.大脑的血液流动.认知障碍是一种认知障碍.神经血管合器的神经血管合器普雷斯比库西斯是什么意思

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