天然多:一种减少结直肠癌的保护性方法
Joel Okpoghono1, Endurance F Isoje2, Ufuoma A Igbuku3
1Department of Biochemistry, Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria.
Heliyon
|July 4, 2024
概括
天然多在通过向分子通路和癌症干细胞来对抗结直肠癌 (CRC) 方面表现有前途. 需要进一步的临床研究来确认它们的有效性并克服生物可用性挑战.
科学领域:
- 在瘤学瘤学.
- 自然产品化学 自然产品化学
- 分子生物学分子生物学
背景情况:
- 结肠直肠癌 (CRC) 是一个重要的健康问题,原因多元,包括饮食和生活方式.
- 天然多醇对抗CRC具有强大的抗癌性质.
- 了解这些特性对于开发新的治疗策略至关重要.
研究的目的:
- 综合审查天然多对结直肠癌的防御机制.
- 在结肠癌模型中分析特定多的安全性,有效性和生化作用.
- 以指导基于多的CRC干预措施的未来研究.
主要方法:
- 使用主要科学数据库 (PubMed,Scopus,Science Direct,Web of Science) 进行了系统的文献审查.
- 178篇摘要的初步选发现了相关的研究.
- 详细审查和分析了145项选定的研究.
主要成果:
- 自然的多调节了参与CRC发展的关键分子和信号通路.
- 聚醇可以通过调节肠道微生物群和癌症干细胞来抑制瘤生长和产生.
- 诸如低水溶性和生物可用性等挑战限制了多的有效性,建议结合疗法或纳米载体系统.
结论:
- 天然多代表着对结直肠癌的有前途的治疗途径.
- 进一步的临床研究对于验证它们的有效性和优化输送方法至关重要.
- 聚醇和先进的输送系统的协同使用可能会提高治疗结果.
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