适应性自然杀手细胞表达在血液和固体癌症中对细胞巨乳病毒感染的反应中
Suruthimitra Okpoluaefe1,2, Ida Shazrina Ismail1,3, Rafeezul Mohamed1,3
1Department of Biomedical Science, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Bertam, Kepala Batas, Penang, Malaysia.
Heliyon
|July 4, 2024
概括
适应性自然杀手 (NK) 细胞表现出类似记忆的特性,并被人类细胞巨乳病毒 (HCMV) 感染扩大. 这些细胞显示出在免疫治疗中增强抗瘤反应的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 病毒学 病毒学
背景情况:
- 自然杀手 (NK) 细胞传统上被视为天生的免疫细胞.
- 一个NK细胞的子集显示了适应性免疫特征,包括持久性和增强的细胞毒性.
- 人类细胞巨核病毒 (HCMV) 感染是适应性NKG2C+NK细胞扩张的已知驱动因素.
研究的目的:
- 在HCMV感染后,审查与适应性或记忆性NK细胞相关的标记物.
- 探索这些NK细胞在固体癌症和血液恶性瘤中的作用.
- 评估适应性NK细胞在采用性免疫治疗中的潜力.
主要方法:
- 对报告适应性NK细胞标记物后HCMV感染的研究的文献评价.
- 对受体表达模式的分析 (例如NKG2C,CD16,CD2,NKG2A,FCεRγ,KIR).
- 研究影响NK细胞受体表达的表观遗传因素.
主要成果:
- 适应性NK细胞通常具有NKG2C上调和限制KIR表达的特征.
- 适应性NK细胞的表型变异存在于不同的疾病环境中.
- 表观遗传修饰与NK细胞受体表达的重新配置有关.
结论:
- 适应性NK细胞,特别是由HCMV扩展的NK细胞,具有与免疫监测相关的独特特征.
- 这些细胞有望增强抗瘤免疫力.
- 适应性NK细胞的ex vivo修饰为针对癌症的新型采用性免疫疗法提供了潜在的策略.
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